An expanded view of complex traits: from polygenic to omnigenic. Genetic architecture: the shape of the genetic contribution to human traits and disease. An atlas of genetic associations in UK Biobank. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Genetics of rheumatoid arthritis contributes to biology and drug discovery. The role of autophagy in Crohn’s disease. 10 years of GWAS discovery: biology, function, and translation. Initial impact of the sequencing of the human genome. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Complement factor H polymorphism and age-related macular degeneration. All GWAS results can be queried and visualized at the GWAS ATLAS resource ( ).Įdwards, A. Our results provide insights into how genetic variation contributes to trait variation. We find that potential causal variants are enriched in coding and flanking regions, as well as in regulatory elements, and show variation in polygenicity and discoverability of traits. We show that trait-associated loci cover more than half of the genome, and 90% of these overlap with loci from multiple traits. For a subset of well-powered GWASs on 558 traits, we provide an extensive overview of pleiotropy and genetic architecture. We systematically analyzed 4,155 publicly available GWASs. The current availability of hundreds of GWASs provides a unique opportunity to address these questions. After a decade of genome-wide association studies (GWASs), fundamental questions in human genetics, such as the extent of pleiotropy across the genome and variation in genetic architecture across traits, are still unanswered.
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